ACHIEVING TARGET BLOOD PRESSURE LEVELS IN PATIENTS WITH HYPERTENSION COMBINED WITH COMORBID TYPE 2 DIABETES AFTER A STANDARD O.I. Afanasiuk Abstract. More than 80 % of patients with diabetes suffer from arterial hypertension. The combination of these two diseases increase the risk of premature death and disability in patients. The study involved 24 patients with essential hypertension stage II, II and III degree combined with diabetes type II, moderate severity in a state of subcompensation. A combination therapy with ramipril and nebivolol helped to reach the target pressure level after 1 month of treatment, as well as a significant decrease in myocardial stress by 27,28 % (p<0,001), which is a sensitive indicator of changes in the heart. The treatment, being a safe option, significantly improved diastolic function of the heart and had a positive effect on lipid and carbohydrate metabolism. Key words: hypertension, diabetes, antihypertensive drugs. Pyrohov National Medical University (Vinnytsia)
THE STATE OF CARBOHYDRATE AND LIPID METABOLISM AND GLOMERULAR S.V. Biletskyi, O.Z. Novytska, O.A. Petrynych, T.V. Kazantseva Abstract. The article deals with the state of carbohydrate and lipid metabolism, its interrelation with glomerular filtration rate (GFR) in patients with degree II hypertensive disease (degree II HD) associated with type II diabetes mellitus (insulin-independent DM). The patients being examined revealed hyperinsulinemia, insulin-resistance and dyslipidemia, which with concomitant type II DM are more pronounced. There is a tendency to hyperfiltration in patients with II degree HD and significant decrease of GFR with concomitant development of II degree HD and type II DM. disorders of lipid and carbohydrate metabolism in patients with II degree HD and concomitant type II DM are found to be as risk factors in the development of kidney afflictions. Key words: arterial hypertension, diabetes mellitus, carbohydrate metabolism, lipid metabolism, glomerular filtration rate. Bukovinian State Medical University (Chernivtsi)
Pathogenic flora in pneumoempyema and its sensitivity to antibiotics V.V. Boiko, D.Ye. Lopatenko Abstract. In this paper, we investigated the etiologic factor of a pneumoempyema and determined its main pathogens sensitivity to antibiotics. We have found that the flora is polymicrobial, Streptococci showed the greatest sensitivity to third-generation cephalosporins (ceftazidime) antibiotics, fluoroquinolones (gatifloxacin, levofloxacin); staphylococci – a combination of carbapenem and digidropeptidazainhibitor (thienam), combination of penicillin and β-lactamases inhibitor (klaforan), fluoroquinolones (ciprofloxacin), the causative agent of pulmonary infection P. aeruginosa – a combination of carbapenem and digidropeptidaza inhibitor (thienam), a combined preparation of third generation cephalosporins and inhibitor of β-lactamases. Candida species were susceptible to amphotericin B. Key words: pneumoempyema, strain of microorganisms, antibiotic therapy. National Medical University (Kharkiv)
Influence of vitamins C and E on lipid peroxidation processes and T.I. Bondarchuk Abstract. Influence of vitamins (Vit) C and E on the lipid peroxidation processes and activity of NO-synthase system in the pancreas of rats with the epinephrine-induced stress was studied. It was ascertained that Vit C decreased TBA-active products content as well as superdismutase activity more than Vit E under the same conditions. However the decrease of general NOS, eNOS activities and the content of NO2- was more considerable in group with Vit E as compared to the action of Vit C. Both vitamins decreased the activity of iNOS equally. Combined action of Vit C and E under condition of epinephrine-induced stress reduced activity of general NOS and iNOS and the content of NO2- more substantially from those treated with Vit independently, however there was no summation of their effects on studied processes. Key words: vitamin C, vitamin E, lipid peroxidation, superoxide dismutase, NO-synthase system. Danylo Halytskyi National Medical University (Lviv)
COMPARISION INFLUENCE OF CONDITIONED MEDIUM T.S. Herheliuk, O.M. Perepelytsina, M.V. Sydorenko Abstract. This work is a study of mediators and mechanisms of the effect of human mesenchymal stem cells from bone marrow (hMSC BM) on the tumor cell population line MCF-7 (breast adenocarcinoma). It is known that MSCs produce a wide range of cytokines and chemokines, and provide humoral cells interaction. BM MSCs produce tumor necrosis factor (TNF-α), interleukin (IL-1β, IL-2, IL-4, IL-6, IL-8), interferon-alpha (IFN-α). In this study we compared the proliferation, adhesion, survival and antigenic profile of breast adenocarcinoma cells that were cultured with conditioned medium (с-medium) of the MSC and IFN-α. Consequently, it was found that с-medium from MSC inhibited proliferation activity of MCF-7, increased cells adhesion, suppressed the ability to migrate, and reduced the expression of estrogen receptor and epidermal growth factor receptor. Conversely expression of cytokeratins increased, which is a positive sign for the tumor cells of epithelial origin. IFN-α showed a more pronounced effect on the tumor population. These findings suggest that cryopreserved MSC BM has antitumor activity. Also, our data suggest that IFN-alpha is one of the mediators of antitumor effect of MSCs. Key words: IFN-α, mesenchymal stem cells, breast adenocarcinoma, MCF-7.
STATUS OF LIPID PEROXIDATION AND ANTIOXIDANT DEFENCE SYSTEM T.I. Grydzhuk Abstract. The paper analyzes the impact of chemotherapy in patients with chronic lymphocytic leukemia in the functional state of the liver.The formation of differentiated types of drug- induced liver damage, depending on the characteristics of cytostatic therapy has been established. The intensity of lipid peroxidation and antioxidant defence stress in patients with drug- induced liver damage on a background of chemotherapy and the presence of correlation relationships between the intensity of cytolysis and severity of lipid peroxidation have been proved. Key words: chronic lymphocytic leukemia, drug-induced liver damage, lipid peroxidation, antioxidant defence. SHEE «Ivano-Frankivsk National Medical University»
DIFFERENTIATION OF FATTY TISSUE STROMAL CELLS UNDER DIFFERENT D.B. Dombrovskyi Abstract. Fatty tissue has been lately considered by researchers as an accessible source of autological stem cells. The problem of factors which influence the directed differentiation of stem cells is still important. Experimental researches have been conducted on rats with simulated limb ischemia. Stromal-vascular fraction of fatty tissue was injected to the experimental animals both with limb ischemia and to those with intact extremities. Imunohistochemical researches (determination of antibodies expression to von Willebrand factor, of collagen IV type and vimentin) of processes, which take place with introduced multipotential stromal cells, the number of which is great in stromal-vascular fraction of fatty tissue against the background of ischemia and without it, have been conducted. These results allow defining the future subsequent development of this direction of researches. Key words: ischemia, stromal stem cells. Bukovinian State Medical University (Chernivtsi)
BLOOD LOSS EFFECT ON THE DYNAMICS OF INDICATORS
OF BILIGENIC LIVER Т.А. Zayets Abstract. In conditions of experimental сranioskeletal injury the disorders of biligenic liver function indicators proceed with maximum deviations in 7 days of post-traumatic period. The revealed disorders are enhanced by subsidiary blood loss: in bile the content of general bile acids and cholesterol and in 1 day of post-traumatic period – of direct bilirubin and its degree of conjugation becomes significantly lower in all periods of observation. Key words: cranioskeletal injury, blood loss, biliation, liver. SHEI I.Ya. Horbachevskyi State Medical University (Ternopil)
CHANGES OF BLOOD LIPIDS UNDER THE INFLUENCE OF
LOW-FREQUENCY I.B. Zhakun Abstract. The study was aimed to investigate the influence of low-frequency magnetic therapy on parameters of lipid metabolism, depending on the severity of reactive and personsal anxiety. Normalization of blood cholesterol levels were observed after treatment in patients with severe anxiety and low baseline cholesterol levels. Key words: lipids, cholesterol, reactive anxiety, personal anxiety, low-frequency magnetic therapy. Danylo Halytsky National Medical University (Lviv)
EARLY AND DELAYED REACTION OF TEMPORAL LOBE CELLS OF RATS’ Т.І. Kmet Abstract. It has been established that brain cell density is significantly reduced in the temporal lobe after a 20-minute carotid ischemia and one-hour reperfusion. Density and fraction of carotid cells of the temporal lobe with signs of apoptosis increase significantly on the 12th day of the study, due to reducing the number of neurons and especially glial cells. Ischemia-reperfusion lesion of the cerebral cortex in the investigated lobe leads to the most expressed disorders of neuron’s morphometric parameters both in the early and late period of ischemia-reperfusion. Key words: brain, carotid ischemia-reperfusion, neurons, glia, apoptosis. Bukovinian State Medical University (Chernivtsi)
THE ROLE OF TRANSFORMING GROWTH FACTOR -β AND OF MATRIX G.D. Koval Abstract. In the development of endometriosis and
infertility, associated with it, immunological processes play an important
role, ant they are characterized by high activity of cytokines and growth
factors (e.g., transforming growth Key words: cytokines, transforming growth factor-β, matrix metalloproteinase, infertility, endometriosis. Bukovinian State Medical University (Chernivtsi)
FEATURES OF EXERCISE
INDUCED BRONCHIAL ASTHMA COURSE IN SCHOOLCHILDREN WITH POLYMORPHISMS IN O.K. Koloskova, O.G. Hryhola, T.M. Bilous, Ye.P. Ortemenka Abstract. With respect to the principles of bioethics, on the base of allergy department of Chernivtsi Regional Children's Hospital it has been conducted a comprehensive clinical and paraclinical examination of 51 children with symptoms of exercise induced asthma phenotype depending upon the presence or the absence of genes polymorphism of the enzymes of glutation-S-transferase – GSTT1M1. The study showed that the course of the disease was more severe in the patients with deletions of the mentioned genes, though with more rapid effect of standard reliever treatments as compared to the patients with genotype GSTT1+M1+. The patients with exercise-induced asthma in the presence of deletion genes polymorphisms of GSTT1M1 (GSTT1delM1del, GSTT1+M1del or GSTT1delM1+) require a special attention to their environmental enhancement and normalization of their life-style. Key words: children, exercise-induced bronchial asthma, glutation-S-transferase genes polymorphisms. Bukovinian State Medical University, Chernivtsy, Ukraine
Examination of Metabolic Disorders in Postmenopausal Women S.Y. Kosilova Abstract. Climacteric period constitutes a third of a woman’s life. The longer was the period of menopause the more intensive were the signs of obesity, as well as increase of lipid and carbohydrate metabolism, increase of C-reactive protein basal level. C-reactive protein is a risk factor of development of vascular diseases. Increased level of C-reactive protein was found in 74 % of women with obesity. In 30 % of women with longer menopause and more pronounced metabolic disorders, non-insulin dependent diabetes mellitus, Type II was diagnosed, and in 42 % of hypertensive disorders were found. Timely diagnostics and correction of metabolic disorders will reduce the risk of development of cardio-vascular diseases and diabetes mellitus in postmenopausal women, improving their quality of life. Key words: women, postmenopause, metabolic disorders, lipid metabolism, body weight gain, vascular complications. Bukovinian State Medical University (Chernivtsi)
CHARACTERIZATION OF LIPID TRANSPORT SYSTEM IN PATIENTS S.H. Kotiuzhynska, A.I. Hozhenko Abstract.The state of the lipid transport system in patients with different variants of atherosclerosis, depending on the level of heparin in the blood has been examined. It was found that the content of heparin was lowered in all the examined, the degree of heparin drop was more pronounced in cases of atherosclerosis, enhanced by disorders of blood circulation. Disturbances of the lipid transport systems were atherogenic and manifested as an increase in the content of total cholesterol and VLDL, decrease of polyunsaturated fatty acids. We believe that the disorder of the lipid transport system is associated with the depletion of heparin synthesis which should be considered as a possible pathogenesis mechanism of atherosclerosis. Key words: heparin, lipid profile, fatty acids, atherosclerosis Odessa National Medical
University
OPTIMIZATION OF THE REPARATIVE OSTEOGENESIS IN CASE N.B. Kuzniak, M.P. Prodan, S.I. Tryfanenko Abstract. The platelet-rich plasma (PRP) is a natural material which actively helps to stimulate the repair process. The evidence based spectrum for using the PRP is wide and deals with many branches of medicine. In stomatology this method is mostly used in combination with osteoplastic materials in case of the sinus lift surgery, augmentation of the alveolar crest, periodontal and implanting intervention. In this research we used PRP for optimization of the reparative osteogenesis after an atypical tooth extraction. Key words: the platelet-rich plasma, atypical tooth extraction, reparative osteogenesis. Bukovinian State Medical University (Chernivtsi)
Hygienic status of THE oral cavity in patients with chronic colitis N.V. Manashchuk Abstract. The article describes the results of a determination of hygienic indices in patients with chronic colitis. An intercommunication between oral health status and severity of dental diagnosis in this category of patients has been shown, in particular, the worse is the hygiene, the deeper is the pathology in the periodontium. Key words: chronic colitis, hygienic indices, generalized periodontitis, catarrhal gingivitis. SHEE «I.Ya. Horbachevsky Ternopil State Medical University»
ENDOTHELIAL DYSFUNCTION AND MEANS OF ITS CORRECTION IN PATIENTS V.M. Miziuk Abstract.The paper studies endothelial dysfunction in patients with arterial hypertension and concomitant heart failure using, besides basic therapy, selective inhibitor of if-channels of cardiac sinus node cells ivabradine. It was determined that patients with hypertension without heart failure are characterized by less pronounced changes of endothelial function. Additional use of ivabradin besides basic therapy induces a decrease of heart rate and promotes normalization of serum endothelin-1 level in patients with hypertension and heart failure. Key words: endothelial dysfunction, endotelin-1, heart rate, ivabradіn. SHEE «National Medical University» (Ivano-Frankivsk)
THE DISTURBANCE OF LARGE INTESTINAL MICROBIOTA V.D. Moskaliuk, I.V. Balanіuk Abstract. In 76 patients with HIV-infection/AIDS a disturbance of microbiocenosis of the large intestine showing up the deficit of obligate microflora, and an increase of opportunistic microorganisms have been found. At all of the clinical stages of HIV-infection frequency of development of dysbiosis/disbacteriosis was significantly higher than in practically healthy individuals (P<0,05-0,001). Strong direct correlation of dysbiosis/disbacteriosis depth with progress of HIV-infection has been established, which represent its clinical stages (r=0,74...0,91). Key words: HIV-infection/AIDS, microflora, large intestine, cavity. Bukovinian State Medical University (Chernivtsi)
PREVALENCE OF STOMATOLOGIC PATHOLOGY IN PERSONS I.K. Novitska1, A.I. Chelii2 Abstract. The purpose of researches consisted in studying functional activity of salivary glands and prevalence of stomatologic pathology in persons with Shegren's illness. Results of researches showed that damage of salivary glands at Shegren's illness is accompanied by a decrease in functional activity of salivary glands. The increase in prevalence of caries and inflammatory diseases of the mucous membrane of an oral cavity has been revealed. Key words: Shegren's illness, salivation, stomatologic diseases. 1 National Medical University (Odessa)
NONSPECIFIC BODY REACTIVITY IN PATIENTS WITH DIABETES O.A. Olenovych Abstract. According to the results of complex assessment of integral haematological coefficients the development of endogenous intoxication was revealed in case of diabetes mellitus, whose intensity depends on the type of the disease and causes immune system disorganization. The decrease of functional activity of specific immunity as well as nonspecific one in case of diabetes mellitus leads to deregulation of cellular and humoral reactions and depends on diabetes type: in diabetes type 1 the reduction of nonspecific immunoresistance is contributed by microphages, in diabetes type 2 – by macrophages, accompanied by the deficiency of specific immune defense, reliably more significant in diabetes type 2. Кey words: diabetes mellitus, nonspecific body reactivity, integral haematological indices. Bukovinian State Medical University (Chernivtsi)
DYNAMIC PARAMETERS OF HOMEOSTASIS UNDER THE INFLUENCE M.A. Orynchak, M.M. Vasylechko Abstract. The condition of coagulation and platelet hemostasis in 125 patients with atrial fibrillation (AF) and with metabolic syndrome (MS) has been analysed. Сoagulation and platelet hemostasis in 125 patients with AF and MS under treatment with acetylsalicylic acid (ASA) (group 1), omega-3 polyunsaturated fatty acids (omega-3 PUFAs) (group 2) and ASA with L-arginine (3 group) during 2 months were measured. It was established that omega-3 PUFAs are more effective compared with ASA/ aspirin with L-arginine and it promotes normalization of fibrinogen, soluble fibrin-monomer complexes (SFMK), D-dimer and improves the platelet aggregative activity (PAA). Key words: atrial fibrillation, metabolic syndrome, haemostasis, treatment SHEI National Medical University (Ivano-Frankivsk)
SOME ASPECTS OF
PATHOGENESIS OF EROSIVE-ULCEROUS N.M. Palibroda, O.I. Fediv Abstract. Von Willebrand factor, tumor necrosis factor-α levels and portal bloodstream were examined in 47 patients with liver cirrhosis and 8 apparently healthy persons. The increase of von Willebrand factor and tumor necrosis factor-α levels were found to lead to the development of erosive-ulcerative lesions of gastric mucosa. The abnormalities of portal resistance, von Willebrand factor and TNF-α are interrelated data which play a certain role in occurrence of erosive-ulcerative lesions of gastric mucosa in patients with liver cirrhosis. Key words: liver cirrhosis, erosive-ulcerous gastric lesions, von Willebrand factor (vWF), TNF-α, congestive index. Bukovinian State Medical University, Chernivtsi, Ukraine
CLINICAL AND LABORATORY CHARACTERISTIC AND AGE FEATURES T.V. Pokrovska Abstract. 123 patients with acute and chronic EBV infection were under observation. The aim of this study was to determine differences in clinical course of acute and chronic diseases. Diagnosis in all patients was confirmed by serologic tests results. We described 3 most common variants of chronic EBV infection: reactivation, incomplete remission and atypical reactivation. The most frequent in patients with chronic EBV infection weretoxical, lymphoproliferative, cardiac and arthralgic syndromes. Key words: Epstein-Barr virus infection, serologic tests result, reactivtion, late reactivation, atypical reactivation. Danylo Halitskyi National Medical University named after (Lviv)
COMPARATIVE ANALYSIS OF MONOCYESIS AND MULTIPLE GESTATION COURSE L.I. Sehedii1,2, О.I. Prokopiv1 Abstract. The data of comparative clinical and statistical analysis of gestation process and pregnancy outcome after IVF & ET in the observation period from 2008 through 2012 have been presented. For a set of initial parameters (age structure; cases, duration and infertility factors, the choice of controlled ovarian stimulation protocol) the studied groups did not differ. It has been concluded, that multiple gestation has a aggravating impact on pregnancies achieved in the result of IVF & ET, which was manifested in statistically more frequent, in comparison to monocyesis, cases of late miscarriage threat, intrauterine growth retardation of fetus (fetuses), preterm labour, adverse perinatal outcomes instances, which has been supported by the corresponding findings of the research in both monocyesis and multiple pregnancy groups. A substantial role in aggravating impact on pregnancy also refers to anemia, which statistically more frequently develops in women with a multiple gestation in comparison to those with monocyesis. Key words: In vitro fertilization, multiple gestation, gestation course, aggravating factors perinatal outcomes 1Lviv Regional Clinic Perinatal Center
SPECIFIC FEATURES OF CHRONORHYTHMOLOGIC CHANGES OF THE EXCRETORY S.B. Semenenko Abstract. The paper investigates the specific features of chronorhythmologic changes of the excretory function of the kidneys under the hyperfunction of the pineal gland. It has been established that the hyperfunction of epiphysis led to disturbances of the phasic structure of the excretory function of kidneys in relation to chronograms of the intact group of rats, which was characterized by significant changes of urinary rhythm with reduction of its mezor and amplitude. Key words: circadian rhythm, kidneys, pineal gland. Bukovinian State Medical University (Chernivtsi)
ENTEROBIasiS CAUSED CHANGES IN THE MUCOUS V.O. Skliarova, K.I. Bodnia Abstract. The paper presents the changes in the skin of the external genitalia and perianal area, as well as in the mucous caused by enterobiasis. Enterobius vermicularis infestation has been identified in 60 % of patients with changes in the skin and mucous membranes. The influence of mature pinworms and their eggs on the vulva, causes a local reaction, which is accompanied by itching, discomfort, swelling, change in consistency and color of vaginal discharge. Only in 30 % of infected patients the complaint "night itch" was noted. Colposcopy changes of the vaginal mucosa and cervix have been detected in all women with enterobiasis. Key words: enterobiasis, gynecology, external genitalia. 1Danylo Halytsky National Medical
University (Lviv),
Pathogenetic features of hypertension treatment in patients V.K. Tashchuk, V.I. Denysiuk*, H.І. Hrebtii Abstract. The study analyzed the performance of the structural remodeling of the myocardium and vascular endothelial function in patients with hypertension and varying body weight during the 3- and 6-month antihypertensive (lisinopril, amlodipine) and lipid-lowering (atorvastatin) therapy. Results of the study show that the smallest speaker regression of left ventricular hypertrophy and improvement of endothelial function of the vessels is determined in patients with deficiency of body weight. Key words: hypertension, obesity, underweight, structural and geometric left ventricular remodeling, endothelial dysfunction. Bukovinian State
Medical University (Chernivtsi)
THE SYSTEM OF NITROGEN OXIDE GENERATION OF SMALL INTESTINE A.S. Tkachenko, V.H. Hopkalov, М.А. Orlova Abstract. The activity of endothelial and inducible NO-synthases and the content of S-nitrosothiols were studied in the small intestine homogenates of rats with chronic experimental gastroenterocolitis caused by food additive carrageenan intake during 2 and 4 weeks. It was established that carrageenan intake during 2 weeks led to a decrease of eNOS activity and increased the activity of iNOS in small intestine homogenate, causing increased production of NO and, therefore of S-nitrosothiols. A decreased NO synthesis in four-week use of carrageenan indicated a potential role of NO deficiency in the development of microcirculatory disorders and chronic inflammation. Key words: gastroenterocolitis, carrageenan, rats, nitric oxide, S-nitrosothiols. National Medical University (Kharkiv)
PATHOGENETIC
SUBSTANTIATION TO CORRECT DISORDERS OF THE BLOOD PLASMA FIBRINOLYTIC SYSTEM IN
PATIENTS WITH CHRONIC K.A. Chympoy, N.V. Pashkovska, O.I. Fediv, N.M. Pavlibroda Abstract. The dynamics of the indices of fibrinolysis and cellular adhesion in patients with chronic diffuse liver diseases against the ground of administration of “Triovit”, a selenium-containing drug, has been studied. The administration of “Triovit” in a comprehensive therapy of patients with chronic diffuse liver diseases was found to improve the indices of the blood plasma fibrinolytic system, to reduce adhesive cellular properties and to increase total enzymatic activity of the blood plasma. Key words: chronic diffuse liver diseases, cellular adhesion, fibrinolysis, Triovit. Bukovinian State Medical University, Chernivtsi, Ukraine
Prevalence AND PECULIARITIES OF CLINICAL SIGNS OF PERIODONTIUM N.V. Chornii Abstract. This paper presents the results of a study of periodontal status in patients with chronic pancreatitis. The study established the high prevalence of periodontal disease in individuals with chronic pancreatitis.The disease manifested itself in a form of generalized chronic catarrhal gingivitis and chronic generalized periodontitis of mild and moderate degrees. Key words: chronic pancreatitis, periodontal disease. SHEE «Ternopil State Medical University I.Ya. Horbachevsky»
EVALUATION OF CONTROL
OVER THE BRONCHIAL ASTHMA IN PERIOD O.O. Shakhova, I.B. Sichkar* Abstract. At the basis of a complex examination of 63 adolescents it was revealed, that the signs of local inflammation in the bronchi and the increase of their nonspecific hyperresponsiveness remained in some of patients with asthma during the clinical well-being period with the absence of clinical symptoms. It was shown that the lower than 40.0 mmol/l content of nitrogen monoxide metabolites in the condensate of exhaled air increases the likelihood of retention of control: relative risk = 4,3 (while assessing the level of control by the ACT questionnaire) and 5,5 – in the evaluation of control level by the GINA questionnaire. Due to this the basic therapy is effective in almost every child, because the minimal number of patients needed to be treated to obtain a positive result is 1,3, according to ACT and GINA tests. Key words: asthma, teenagers, bronchial inflammation, exhaled breath condensate. Bukovinian State Medical University (Chernivtsi)
STATE OF SOME INDICATORS OF IMMUNOCYTOKINE PROFILE IN YOUNG PEOPLE G.I. Shumko Abstract. The condition of some indicators of immunocytokine profile in young adults with bronchial asthma has been studied. It showed an increasing level of interleukin-1b, tumor necrosis factor-a and immunoglobulin E in the blood. Factors which support the progression of asthma in young adult are the violation of immunocytokine profile due to the increasing level of interleukin-1b, tumor necrosis factor-a, which is accompanied by an increase of blood immunoglobulin E. Key words: bronchial asthma, young age, interleukin-1b, tumor necrosis factor-a, immunoglobulin E. Bukovinian State Medical University (Chernivtsi)
Correction of genital tract dysbiotic states of pregnant women N.V. Shchuruk Abstract. The article presents some data of effectiveness of two-step approach to genital tract treatment of pregnant women with miscarrages. According to the obtained data, the vaginal dysbiosis of pregnant women with the risk of miscarrages was trated by means of probiotic – bioenteroseptic “Enterogermina” on the the second stage of treatment. It resulted in recovery of vaginal microbiocenosis in 28 (87,5 %) out of 32 patiens of the main group, while in the control group this index was 37,5 %. It is recommended to use the proposed way of treatment in the obstetric and gynecologic facilities, as the most effective method. Key words: miscarriage, vaginal dysbiosis, probiotic - bioenteroseptic "Enterogermina". Danylo Halytskyi National Medical University (Lviv)
Analysing the influence of factors of birth cohort maturing on V.P. Klymeniuk, O.M. Ocheredko Abstract. We investigated the local regularities of disability incidence due to cardiovascular diseases in Zhytomyr oblast over 1999-2008 by strip-split-plot design. By using geographical mixed model we ascertained the peculiarities of disability distribution among cohorts, age groups and time periods (APC). Data analysis was carried out on the base of hierarchical nonlinear mixed model. Results bear witness to enhanced local heterogeneity in disability rates due to irregularity in distribution of APC factors. Each APC factor rendered significant modification to geographical distribution of disability rates. Key words: disability, birth cohorts, cardiovascular diseases, geographical model. Pyrohov National Medical University (Vinnytsia)
Analysis of the quality of treatment and rehabilitation activities V.I. Shevchuk, V.Y. Zaburianova, M.V. Vernyhorodska, I.A. Iliuk, V.S. Vernyhorodskyi Abstract. The main aspects of providing the patients and disabled people suffering from Chronical Obstructive Pulmonary Diseases (COPD) and asthma with medical and expert assistance by examining health expert documentation of patients in the Institute clinic in 2013 (48 people). Unsatisfactory organization of pulmonology care, poor quality of diagnosing and treatment, as well as imperfection in determining the vital activity of people with bronchoobstructive diseases were found. The methods for improving the quality of rehabilitation of patients and disabled as victims of COPD and asthma were suggested. Key words: disability, chronic obstructive pulmonary disease, (COPD), asthma, rehabilitation. M.I. Pyrohov National Medical University (Vinnytsia)
STATISTICAL INDICATORS OF EPIDEMIOLOGY OF COLORECTAL CANCER AMONG V.V. Shulhina, O.I. Ivashchuk, S.Y. Kravchuk, I.Y. Hushul Abstract. Statistics indicators of prevalence, incidence and mortality caused by colorectal cancer in the population of the world, Ukraine and residents of Chernivtsi region with conducted taking into consideration patients’ gender and stage of disease. Key words: cancer, intestine, epidemiology. Bukovinian State Medical University (Chernivtsi)
ARTERIAL HYPERTENSION, DYSFUNCTION OF KIDNEYS AND OSTEOARTHROSIS T.O. Ilashchuk, N.V. Shvets, T.V. Zakharchuk Abstract. Analysis of influence of high blood pressure over the functional state of kidneys in patients with arterial hypertension and concomitant osteoarthrosis, and overweight with estimation of efficiency of omega of -3-polyunsaturated fatty acids application has been carried out in the review of literature. Hormones and cytokines produced by fatty tissues co-operate at the level of the neuronal systems, causing overactivaty of sympathetic nervous system, increase of blood pressure level in case of excessive weight. Unity of pathogenesis of the investigated pathological processes is shown, for treatment of which omega-3-polyunsaturated fatty acids prescription is rational; that will become a basis of perfection of pathogenetically reasonable and inculcated in medical practice approach for treatment of metabolic disorders. Key words: arterial hypertension, osteoarthrosis, overweight, dysfunction of kidneys, omega-3-polyunsaturated fatty acids. Bukovinian State Medical University (Chernivtsi)
Pathogenetic features of type B gastritis in CHILDREN T.V. Sorokman, S.V. Sokolnyk, M.G. Hinhuliak, N.O. Popeliuk, D.R. Andriichuk Abstract. The data of the scientific literature on etiology and pathogenesis features of type B gastritis have been analysed. Key words: type B gastritis, pathogenesis. Bukovinian State Medical University (Chernivtsi)
SYNDROME OF HYPERANDROGENISM AND THYROID STATUS IN WOMEN P.M. Liashuk, A.A. Iliushyna, S.V. Hluhovska, O.V. Hrabovetskyi, I.V. Skhodnytskyi Abstract. The article presents a case of adrenogenital syndrome in women, accompanied by a rare manifestation – galactorrhea. A version of the pathogenesis of galactorrhea and a possibility of pathogenetic therapy are discussed. Key words: adrenogenital syndrome, thyroid status, hyperandrogenism, galactorrhea, treatment. 1Bukovinian State Medical University
(Chernivtsi)
NEW WAYS OF DIAGNOSING AND TREATING THE HEART FAILURE V.K. Tashchuk, O.S. Polianska, O.I. Hulaha Abstract. New ways of the diagnosing and treating the heart failure according to modern recommendations of Ukrainian Аssociation of Cardiology have been presented in the article. Key words: heart failure, myocardium, aldosterone. Bukovinian State Medical Unsversity (Chernivtsi)
SOME ASPECTS OF MASTERING PRACTICAL SKILLS BY STUDENTS V.V. Berezniuk, A.V. Kovtunenko, A.V. Zaitsev, A.A. Chornokur Abstract. The article reflects the current requirements for the study of «Otorhinolaryngology" against the background of the introduction of the European system of education into the Ukrainian one. In order to optimize the learning process and for the most effective mastering practical skills by students, a constant introduction of qualitatively new methodological support: guidelines, tests, computer technology, training videos, are needed. Key words: otolaryngology, reform of higher education, teaching, training of general practitioners. State Medical Academy (Dnipropetrovsk)
Ways of improving the teaching of surgical disciplines cycle for S.Yu. Karatieieva, O.I. Khomko, R.I. Sydorchuk, O.M. Plehutsa Abstract. According to the principles of credit-module system in educational process, we developed new curricula for teaching "Nursing in surgery". This article presents possible ways to improve the efficiency of the practical classes with students enrolled into specialty «Nursing» (ECL – «junior specialist»). In particular, the use of interactive classes model of didactic process effectively improves the digestion of thematic material. The main aim is to encourage active potential of students by involving them in the dialogue, open conversation, discussion of surgical patients’ clinical problems, evidence, and argumentation of their own view, analysis of their actions while dealing with situational and clinical tasks as well as working in the medical office and with patients. In the process of interactive teaching, students learn to think critically, make thoughtful decisions, communicate with each other. Key words: surgical disciplines, teaching, students. Bukovinian State Medical University (Chernivtsi)
WRITING A DEGREE WORK AS A KEY METHOD OF SPECIALISTS TRAINING I.Р. Kutynska Abstract. One of the key methods of specialist training optimization in the specialty "Pharmacy" is writing and defense of degree works. This kind of research plays an important role in forming the creative potential of students, aimed to developing analytical and creative abilities, intelligence, memory, improving the learning of educational material in accordance with state educational standards. Key words: degree work, knowledge, experimental tasks, practical skills. SHEE National Medical University (Ivano-Frankivsk)
Organisation of studying process UNDER credit-module system I.A. Plesh, L.D. Boreiko Abstract. The article analyses the experience of teaching therapeutic subjects to Nursing students under credit-module system at the Department of Patients Care and Higher Nursing Education. Key words: credit-module system, nurse bachelor. Bukovinian State Medical University (Chernivtsi)
SPECIFIC CHARACTERISTICS OF TEACHING PHARMACOLOGY TO FOREIGN I.B. Samura Abstract. The design of physician programs creates special challenges for providing pharmacology education. The article presents examples pertaining to improving teaching methods in pharmacology to foreign students at Medical Department. The paper has revealed peculiarities of theoretical knowledge and practical skills acquisition in the process of teaching pharmacology, and the stimulation technics for cognitive interest of students have been discussed. In particular, it has been analyzed the contributing factors that prove the need for the introduction and regular application of interactive teaching methods, testing students, the discussion of complex and unresolved scientific problems of dynamic and constantly developing science of pharmacology, and its interaction with other modern biomedical sciences. Key words: teaching process, pharmacology, foreign students. State Medical University (Zaporizhzhia)
ELEMENTS OF CREDIT MODULE SYSTEM IN TRAINING INTERNSHIP DOCTORS FOR V.S. Khilchevska, L.V. Koliubakina Abstract. The paper shows that the effectiveness of training interns for the state test licensed exam depends on the quality of education at the core department, using elements of credit module system. Key words: internship, test control, module «Emergencies». Bukovinian State Medical University (Chernivtsi)
THE DEPARTMENT OF FORENSIC MEDICINE IN THE PAST AND PRESENT V.T. Bachynskyi, I.G. Savka, O.Ya. Vanchuliak, O.F. Kulyk Abstract. In this article, the history of the Department of Forensic Medicine and Medical Law of the Bukovinian State Medical University was analyzed in the context of the stages of formation of forensic medicine as an educational discipline. The historical and scientific portraits of the heads of department and teachers of the Department of Forensic Medicine and Medical Law are shown. The formation and prospects of cooperation between the Chernivtsi regional bureau of forensic medicine and the department on the path to a united scientific and practical complex, which was created thanks to the instructional, research and practical activities of the department staff are described. Key words: Department, Forensic Medicine, Medical Law, history, science Bukovinian State Medical University (Chernivtsi)
METABOLIC DISORDERS IN HYPERTENSION PATIENTS AS SCIENTIFIC AREA S.V. Biletskyi, O.A. Petrynych, T.V. Kazantseva Abstract. The paper generalizes the results of a scientific research at the department of family medicine concerning the study of metabolic disorders in hypertension patients and their changes caused by a pathogeneticaly based treatment. Key words: department, scientific area, hypertension, metabolic disorders. Bukovinian State Medical University (Chernivtsi)
SCIENTIFIC ACHIEVEMENTS OF THE DEPARTMENT OF NERVOUS DISEASES, V.M. Pashkovskyi, I.I. Krychun Abstract. The presented article reflects the basic scientific achievements of the department of nervous diseases, psychiatry and medical psychology from the day of its foundation to the present time. Key words: Bukovinian State Medical University, department of nervous diseases, psychiatry and medical psychology, scientific achievements. Bukovinian State Medical University (Chernivtsi)
PAST, PRESENT AND FUTURE OF MEDICAL BIOLOGY DEPARTMENT V.P. Pishak, R.Y. Bulyk, O.I. Zakharchuk, N.V. Chernovska Abstract. The work of Medical Biology Department of Bukovinian State Medical University over 70 years has been analysed. General directions of teaching, researching and educational work at the junction of two centuries have been characterised. Key words: medical biology, educational process. Bukovinian State Medical University (Chernivtsi)
Нistory of formation of
thephthisiology and pulmonology L.D. Todoriko, A.V. Boiko, V.P. Shapovalov, V.O. Stepanenko, V.I.Slyvka, I.O. Semianiv, Abstract. The directions of scientific, methodical and clinical activity of the Phthisiology and Pulmonology department staff at each stage of its formation as well as the prospects of its development have been covered in this article. The relevance of further researches concerning the effectiveness of modern chemotherapy program and creation of new vaccines and medications to optimize treatment of patients with drug resistant TB was grounded. Key words: Phthisiology and Pulmonology department, history, scientific directions, tuberculosis, drug resistant TB Bukovinian State Medical University (Chernivtsi)
DEVELOPMENT OF THE UTERINE TUBES AT THE END OF THE FETAL PERIOD B.Yu. Banul, F.D. Marchuk Abstract. The authors have studied the features of syntopy and external structure of the uterine tubes at the end of the fetal period of human ontogenesis by means of fine preparation under control of a binocular loupe MBS-10 and morphometry. Key words: uterine tubes, uterus, fetuses, syntopy, human. Bukovinian State MedicalUniversity (Chernivtsi)
FEATURES OF ADJUSTING THE AGGREGATE STATE OF
WOMEN’S BLOOD I.V. Byrchak Abstract. The general coagulation blood potential, fibrinolytic activity of plasma, antiplasmin and plasmin potential activity, fibrinogen level in blood serum, antithrombin III activity, concentration of soluble fibrin-monomer complexes in the blood serum were estimated in women with anaemia of I degree on a background of the dysfunctional uterine bleeding. The changes of blood fibrinolytic potential have secondary nature, that is conditioned by activating the trombinogenesis and fibrinogenesis externally. The hypercoagulation develops by activating the hemopexis through the external mechanism of protrombinasa formation, which is accompanied by a decrease of anticoagulation potential and an increase of aggregation features of thrombocytes. Key words: dysfunctional uterine bleeding, haemostasis system. Bukovinian State Medical University (Chernivtsi)
THE CHARACTERISTIC OF EXCRETORY AND ACIDREGULATING RENAL FUNCTIONS UNDER ALUMINUM SALTS ACTION IN MATURE AND IMMATURE RATS Y.M. Vepryuk Abstract. In experiments on 36 immature and mature males of nonlinear albino rats weighing 0,60-0,10 0,16-0,21 kg respectively it was shown more significant nephrotoxic effect of the studied environmental factor on the immature animals, judging from the fact that the concentration of protein in the urine and its excretion increased against the background of the introduction of aluminum salts in immature rats. The mature rats tended to increase the excretion of ammonia and a significant ammonia ratio increase when aluminum salts were introduced. Key words: kidney, aluminum chloride, immature rats, mature rats. Bukovinian State Medical University (Chernivtsi)
MATURING OF THE HUMAN PLACENTA, MATURITY OF THE UTERO-PLACENTAL A.V. Hoshovska, V.M. Hoshovskyi Abstract. Authors give histological criteria of maturity of the uteroplacental region at the separate intervals of gestation. The results of this investigation can be recommended for the diagnostics of preterm or retarded maturing of the human placenta as manifestation of afterbirth insufficiency. Key words: utero-placental area, criteria of maturity, diagnostics. Bukovinian State Medical University (Chernivtsi)
RISK OF ARTERIAL HYPERTENSION DEVELOPMENT DUE TO T393C GENE I.A. Dudсhenko Abstract. According to foreign researchers, T393С gene polymorphism of α-subunit of the G-protein (rs7121) affects the sympathetic-adrenal system and the risk of hypertension. There are also data on the dependence of the manifestations of this polymorphism on the associated risk factors. However, these data are contradictory, which may be explained by ethnic differences in patients. In Ukraine there were no studies on this issue. We have studied 166 hypertensive patients and 90 healthy individuals. Determination of the polymorphism was performed by polymerase chain reaction with subsequent analysis of restriction fragments. The study found no statistically significant difference in the distribution of genotypes T393T, T393С, С393С in patients with hypertension and healthy subjects (p>0,05). The risk for hypertension in carriers of genotypes T393T + T393С relatively to С393С genotype was not significantly different (OR=1,44, 95% CI 0,74-2,80; p=0,283). During the analysis of the effect of smoking on the manifestations of T393С gene polymorphism α-subunit of the G-protein, no statistically significant difference were found (p>0,05). T393C gene polymorphism of α-subunit of G-protein did not affect the risk of hypertension. Key words: hypertension, gene polymorphism, G-protein. Medical Institute of State University (Sumy)
ECHOGRAPHIC CHARACTERISTICS OF EMBRION DEVELOPMENT D.O. Kondria, I.V. Kalinovska Abstract. The article presents the results of ultrasound examination of healthy pregnant women and those with miscarriages in early terms of gestation. The changes which are typical for primary placental insufficiency onset have been detected. Key words: pregnancy, placental insufficiency, chorion. Bukovinian State Medical University (Chernivtsi)
HORMONAL ADAPTATION OF THE FETAL-PLACENTAL COMPLEX S.Y. Kosilova Abstract. The course of pregnancy and labour in women with preeclampsia considerably determines maternal and perinatal morbidity and mortality. The study of the hormonal function of the fetal-placental complex appears to be rather topical in this respect. The research conducted gave the evidence that the pregnant with preeclampsia develop placental dysfunction. It results in a decrease of hormone production in the fetal-placental complex, development of complications during gestation, labour, conditions of the fetus, and requires a hormone-correcting therapy. Key words: pregnancy, preeclampsia, placental dysfunction, hormones. Bukovinian State Medical University (Chernivtsi)
Analysis of antenatal risk factors in multiple pregnancies О.V. Kravchenko Abstract. We examined 42 pregnant women with twins who gave birth in 2013 in the clinical maternity hospital № 2 of Chernivtsi. It was established that multiple pregnancy is more common in multipara women of age group 25-30 years (52,3 %). The course of pregnancy with twins is aggravated in 78,5 %, which is much higher than the average population index. Dichorionic diamniotic twins dominated (57,1 %) in the structure of multiple pregnancy. The preterm labor with dichorionic diamniotic twins occur 3 times less frequently (23,6 %) than in monochorionic diamniotic multiple pregnancies (75,4 %). Key words: мultiple pregnancy, antenatal risk. Bukovinian State Medical University (Chernivtsi)
Perinatal risks at
the repeated caesarean section and vaginal O.V. Kravchenko, V.A. Varvus Abstract. 251 pregnant women were under observation with a uterine scar after previously performed cesarean section. 225 women were operated one more time. 26 women had delivery through natural genital tract (10 % of the pregnant women with a uterine scare). It was established that the delivery occurred physiologically due to the correct assessment of risk factors for vaginal birth in women with a uterine scar. The presence of uterine scar in the lower segment does not significantly affect the nature and duration of labor. An increased fetal weight at vaginal birth in women with a uterine scar to 300g does not increase obstetric and perinatal complications. Thus, the study has shown that an increase of complications such as placentation in the scar and scar failure is high risk of maternal and perinatal pathology in pregnancy with a uterine scar. Key words: uterine scar, perinatal risk. Bukovinian State Medical University (Chernivtsi)
PRODUCTION AND RECEPTION OF THE GROWTH FACTOR IN THE PLACENTA O.A. Kuzmina Abstract. 30 women with physiological pregnancy and 28 women with gestosis were examined. In the early chorion obtained after abortion and on the full-term placenta the content of the epidermal growth factor (EGF), vascular-endothelial growth factor (VEGF) and their receptors were studied by means of the ELISA method. In the process of normal gestation the increase of the placental production both of the EGF and VEGF was found. During the pregnancy complicated with gestosis and miscarriage in the first trimester the content of EGF and its receptor was lower compared to the physiological values. For VEGF and its receptor opposite changes were found: the increase of quantity of the growth factor and the decrease of its receptor. In the case of gestosis and term pregnancy the content of the both growth factors and their receptors was lower than in controls. The revealed changes in production of the angiogenic growth factors and their receptors in the placenta may have the pathogenic importance in the development of gestosis. Key words: vascular endothelial growth factor, epidermal growth factor, receptor growth factors, chorion, placenta. National Medical University (Kharkiv)
OPTIMIZATION OF DAMAGING PERINATAL FACTORS DIAGNOSING IN М.V. Маkаrenko, О.A. Кuzmina Abstract. 74 pregnant women with the symmetric form of intrauterine growth restriction (IUGR) at the term of pregnancy of 27-40 weeks were involved in the study. The conducted analysis showed that the principal cause of symmetric form of IUGR is the complicated course of pregnancy: gestosis (55 %) and protracted threat of pregnancy interruption (35 %). The obtained results allowed to distinguish the criteria of fetal chronic hypoxia and attribute them to the damaging perinatal factors in IUGR. Key words: Intrauterine growth restriction,damaging perinatal factors, diagnostics. National Medical University (Kharkiv)
A case of late diagnosing Dermal Focal Hypoplasia IN A child N.I. Pidvysotska1, І.V. Lastіvka1, L.V. Boiko2, І.M. Valуhurskyі2 Abstract. Dermal focal hypoplasia is a rare X-linked dominant meso-ectodermal disorder. The described case of Goltz’s syndrome shows clinical manifestations, a need for a multidisciplinary assessment, diagnostic and continuous monitoring of this pathology. Key words: skin atrophy, dermal focal hypoplasia. 1Bukovinian State Medical University
(Chernivtsi),
VARIANTS OF THE FETUS’S UTERUS ANATOMY D.V. Proniaiev Abstract. Considering the complexity of prenatal and postnatal diagnostics of female gynecological pathology, the examination of 50 dead fetuses has been conducted by means of classical anatomical methods of investigation. The objective of the study was to find the regulations of normal and pathological perinatal uterine morphogenesis. As the result of the study conducted, normal and pathological forms of the uterus and their characteristic affiliation to a certain period of the fetal development have been detected. At the beginning of the fetal period sulcate and two-humped uterus prevails. Flat and protruding shape of the uterine fundus is found in the mature fetuses. The processes of definite organization of the uterine structure have been found to occur in the postnatal period of ontogenesis. Morphological peculiarities of the uterine structure have been differentiated to determine the age of the fetus. Key words: uterus, perinatal period, fetus, human. Bukovinian State Medical University (Chernivtsi)
A PROSPECT OF ACUTE CORONARY INSUFFICIENCY DIAGNOSING BY MEANS OF FRACTAL ANALYSIS OF LASER POLARIZATION IMAGES OF THE MYOCARDIUM A.S. Syvokorovska, O.Ya. Vanchuliak, I.L. Bezhenar, O.G. Palyvoda, A.O. Andriichuk Abstract. The article grounds a prospect of using the method of fractal analysis of laser polarization images of the myocardium, highlights diagnostic criteria of structural changes of the cardiac muscle in this pathology. This paper illustrates visually how simple and exact may be marked the area with ischemia which is relevant in modern science. Key words: acute coronary insufficiency, structural changes, diagnostics, forensic-medicine expertise. Bukovinian State Medical University (Chernivtsi)
INFLUENCE OF THE DUAL COX-2/5-LOG INHIBITOR ON THE ACTIVITY OF L-ARHININ/NO SYSTEM IN RAT'S BLOOD WITH EXPERIMENTAL ULCER OF THE STOMACH O.P. Khavrona Abstract. A large spread of stomach ulcer causes the search for new effective gastroprotective drugs, which would possess antioxidant properties. It is established that the disease is accompanied by the imbalance in the system L-arhinin/NO. This is manifested by the activation of the NO-synthase pathway of L-arginine and is accompanied by excessive formation of nitric oxide. It is proved that the use of dual inhibitor COX-2/5-LOG normalizes deviation in the L-arhinin/NO system. This shows antioxidant and cytoprotective properties of the substance. Key words: L-arginine, nitric oxide, arginase, NO-synthase, COX-2/5-LOG inhibitor. Danylo Halytskyi National Medical University (Lviv) |
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