EFFECT OF L-CARNITINE ON THE INDICES OF ENDOTHELIAL DYSFUNCTION B.A.Aliavi, Sh.A. Iskhakov, Sh.K. Muminov, A.K. Tursunbaiev, P.M.Tolipov, M.G. Muhamedova Aim: To evaluate the influence of L-carnitine on inflammatory markers and indicators of endothelial function in patients with acute myocardial infarction without the Q wave. Materials and Methods: 40 patients with verified diagnosis of AMI without Q-wave. All the patients were matched by sex, age, weight and duration of the underlying disease. The patients were randomized into 2 groups. The first group of patients were on a standard basic therapy and additionally administered L- carnitine at a dose 5g/day, II- group consisted of patients who did not receive drugs with metabolic action. In dynamics (on the 1st and 10th day of the treatment) the parameters of endothelium vasodilation and markers of inflammation were evaluated. Results: On the background of the basic therapy in both groups an improvement in endothelial function resulting in an increase of brachial artery diameter was observed. However, the L- carnitine vasodilator effect was more pronounced and persistent as compared to group II. In the dynamics, CRP levels and plasma fibrinogen were more pronounced in the Ist group. Key words: endothelial dysfunction, C-reactive protein, fibrinogen, L-carnitine, nonQ-wave IM. Republican
Specialized Scientific Practical Medical Centre of
CLINICAL EFFICIENCY OF BISOPROLOL IN PATIENTS WITH CORONARY HEART A.B. Alyavi, R.R. Tursunov, Sh.A. Iskhakov, M.A. Babaev, M.G. Muhamedova Abstract. At present, in order to influence the indices of the global contractions of the left ventricles in patients with coronary heart disease effectively, genetic characteristics in receptor structure and particularly adrenoreceptors responsible for sympathoadrenal activity should be considered. Patients division depending on the type of polymorphism gives prerequisites for new efficient algorithms for individual selection of medicines, including β-blockers. Taking into consideration the type of polymorphous marker of ADRB- 1 receptor, it is possible to maximize the effect of β-adrenoceptor, thereby to influence effectively the pathogenic mechanism of the disease. Key words: β-blocker, polymorphism ADRB-1, coronary heart disease. Republican
Specialized Scientific Practical Medical Centre of Therapy and
Indices of bronchial lability in children with atopic and nonatopic L.O. Bezrukov, S.I. Tarnavska, M.N. Garas, O.O. Shakhova Abstract. After comprehensive clinical, laboratory and instrumental investigations of 51 children, who suffer from bronchial asthma, it was determined that in patients with atopic asthma slow acetylation status increased the possibility to detect a severe bronchial lability (bronchial lability index more than 30 %) by 4,4 times compared to the patients with fast acetylation status. For atopic phenotype of disease availability of correlations between bronchial lability indices and bronchial obstruction severity was established (r=0,7, p<0,005) as well as duration of illness (r=0,8, p<0,001), frequency of re-hospitalization of patients (r=0,6, p<0,05). In patients with nonatopic form of the disease relationships between bronchial lability indices and clinical features of disease depending on acetylation status haven’t been reported. Key words: asthma, phenotype, children, bronchial lability, acetylation status. Bukovinian State Medical University (Chernivtsi)
SEMEN ANALYSES EVALUATION IN MEDICAL CENTRE FOR INFERTILITY TREATMENT K.A. Vladychenko, L.T. Savchuk Abstract. Semen analyses, made in Chernivtsi Medical Centre for Infertility Treatment from 2010 to 2012 were studied. The parameters were evaluated as recommended by WHO, 2000. 1,935 men where involved in the study. A general tendency of increasing asthenozoospermia in B category was found. Key words: male infertility, diagnostics, semen analysis. Bukovinian State
Medical University (Chernivtsi)
CORRECTION OF HEPATIC ENCEPHALOPATHY IN PATIENTS WITH LIVER I.M. Havrysh Abstract. 65 patients with liver cirrhosis combined with intestinal dysbiosis have been examined; an assessment of the functional state of the liver, clinical manifestations of hepatic encephalopathy, neuropsychometric tests, intestinal microbiota has been carried out; Lactobacillus and Bifidobacterium as well as Methylsiliconic acid hydrogel were included into the complex treatment. Inclusion of these drugs in the complex treatment resulted in significantly better reduction of subjective and objective signs of cirrhosis, severity of functional and biochemical syndromes, symptoms of hepatic encephalopathy. Key words: liver cirrhosis, hepatic encephalopathy, intestinal dysbiosis, medication of Lactobacillus and Bifidobacterium, Methylsiliconic acid hydrogel. SHEE "Ivano-Frankivsk National Medical University"
DIAGNOSIS OF GENITAL TRACT INFECTIONS IN PREGNANT WOMEN V.V. Harbuziuk, S.P. Poliova Abstract. The article presents data on the diagnosis of genital tract infections in patients with pulmonary tuberculosis, whose pregnancy ended in premature delivery. It is shown that in this contingent of pregnant women, vaginal microflora undergoes qualitative and quantitative changes, early detection of which contributes to the effective prevention of a preterm birth. Key words: premature birth, tuberculosis, vaginal biocenosis, diagnosis. M.I. Pirogov National Medical University (Vinnytsia)
CLINICAL EFFECTIVENESS OF COMPLEX TREATMENT OF PERIODONTAL Z.M. Honta Abstract. Treatment schemes and medical prophylaxis of inflammatory-dystrophic periodontal diseases in patients with schizophrenia are pathogeneticyally considered and developed. The efficiency of the suggested method of complex treatment of periodontal diseases has been proved by the reduction of therapy terms, prolongation of clinical stabilization period, as well as normalization of clinical and paraclinical indicators in patients treated in all terms of supervision. Key words: complex treatment of periodontal diseases, generalized periodontitis, schizophrenia. Danylo Halytsky National Medical University (Lviv)
The sex related effects of intermittent hypobaric hypoxia on the R.R. Dmytrenko, H.I. Khodorovskyi, V.A. Honcharenko Abstract. It is shown in experiments that intermittent hypoxia (equivalent to the altitude 4000 meters, 2 hours per day for 14 days) changes the capacity of the oxidized modification of proteins (OMP) in the gingival tissues of immature albino rats. The result of hypoxic effects depends on the sex of animals: in males it causes a decrease of proteins peroxidation intensity both of basic and neutral nature; in females – only a tendency to decrease of the basic OMP. Functional state of the pineal gland changed by experimental conditions (14 days of illumination – “physiological pinealectomy”, or 14 days of darkness – stimulation of the pineal gland) influenced the effects of hypoxia on the OMP in the gingival tissues. The darkness heightens the decreasing effects of hypoxia on the capacity of OMP in the gingival, which is more pronounced in male rats. Our results suggest that by an application of combination of intermittent hypobaric hypoxia and the darkness it is possible to prevent the process of accumulation of OMP in the gingival tissues Key words: gingiva, hypoxia, photoperiod, oxidized modification of proteins, sex. Bukovinian State Medical University (Chernivnsi)
FEATURES OF FUNCTIONAL STATE OF NEUROHUMORAL REGULATION IN PATIENTS WITH SEROUS MENINGITIS IN THE COURSE OF THE DISEASE D.A. Zadyraka, E.V. Ryabokon, A.V.Abramov Abstract. The paper presents the fact, that in patients with serous meningitis in the course of the disease against the background of reducing intoxication and cerebral symptoms, clinical signs of autonomic dysfunction manifest and they are confirmed by the changes of heart rate variability and hormonal changes still remaining in the majority of patients during the period of convalescence. Key words: serous meningitis, heart rate variability, hormones. State Medical University (Zaporizhzhia)
REMOTE RESULTS OF GENERALIZED PERIODONTITIS TREATMENT M.S. Zaliznyak Abtract. The article presents long-term results of treatment of generalized periodontitis in patients with osteoarthritis using chloride-calcium-sodium mineral water of Novozbruchansk deposit with high salinity and of system administration of osteotropic drugs "Сalcemin" and "Aquadetrim" Key words: generalized periodontitis, osteoarthritis, long-term outcomes treatment. SHEI
«I. Ya. Horbachevskyi State Medical University(Ternopil)
ARTERIAL HYPERTENSION IN WOMEN IN THE CLIMACTERIC PERIOD: CLINICAL, T.O. Ilashchuk, K.O. Voloshynska Abstract. 50 female patients were examined for the purpose of studying the arterial hypertension course during their climacteric period. The results testify that hypertension develops frequently during the menopause due to lack of sex hormones; its psychosomatic and cardiochemodynamic manifestations reduce women’s quality and span of life. Key words: arterial hypertension, climacteric period. Bukovinian State Medical University (Chernivtsi)
MATHEMATICAL COMPUTER-BASED MODELLING OF BIOMECHANICAL A. Kalashnikov, A. Tiazhelov, V. Lazarenko Abstract. The research of the mode of deformation of the “femur – fixation device” system is done for intramedullary nailing of the distal end fractures of the femur (fracture A1 in AO classification) by the finite element method. The models differ by their distance between the plane of fracture and the articular surface of the femur: model 1 – the plane of the fracture is 5 cm from the articular surface of the femur; model 2 – the plane of the fracture is 6,5 cm from it; model 3 – the plane of the fracture is 8 cm from the articular surface of the femur. The received results convincingly demonstrate the advantage, both in terms of strength and stiffness, of the connection formed by intramedullary nailing on the distance of 8cm (model 3). Key words: fracture of the femur, intramedullary fixation, supracondylar fixation, mathematical computer-based modelling. Institute of Traumatology
and Orthopedics of AMS of Ukraine (Kyiv)
INDICATORS
OF SYSTEMIC IMMUNITY IN PATIENTS WITH DIFFERENT Y.P. Karvatska, О.І. Denysenko Abstract. In patients with acne vulgaris – the inhabitants of the natural biogeochemical iodine deficiency region, changes in the immune system that indicate the formation of a secondary immunodeficiency state, mainly T-lymphocytes, and reduced phagocytic activity of phagocytic blood cells that are interdependent with the severity of clinical manifestations of dermatosis have been detected. Key words: acne vulgaris, iodine deficiency area, systemic immunity. INFLUENCE OF LONG LIPID LOWERING THERAPY ON THE MICROELEMENT V.I. Klymenko Abstract. In 66 patients with stable angina tension changes of microelement exchange and instrumental examination findings depending on the general cholesterol level in the blood and during the protracted lipid lowering therapy have been studied. The ambiguous changes of microelement exchange, of intracardiac haemodynamics indices and tolerance to an exertion while taking statins have been shown. Key words: coronary artery disease, statins, microelements. SHEI "National Medical University" (Ivano-Frankivsk)
Hyperglycemia as a component of metabolic syndrome and T.A. Kriachok, L.L. Vavilova Abstract. The results of the
investigation show that the primary disturbances of the carbohydrate
metabolism, Key words: insulin resistance, metabolic syndrome, atherogenesis, inflammation, lipoproteins, carbohydrates. NSC “M.D. Straschesko Institute of Cardiology” National Academy of Medical Sciences (Kyiv)
STATE OF THE BLOOD LIPID PROFILE IN ACUTE PERIOD OF RECURRENT A.V. Kulmatytskyi Abstract. In patients with both primary and recurrent ischemic stroke in its acute period the combined dyslipidemia with no probable differences was found which declared itself in an increase of general cholesterol, cholesterol of low density lipoproteins, cholesterol of extra low density lipoproteins, triglycerides and atherogenic factor at low concentrations of cholesterol of high density lipoproteins. There were no significant differences found between the indexes of lipidogram of different levels of severity in the primary ischemic stroke group as well as in the group of recurrent ischemic stroke, and no significant differences between their same name levels of severity were found either. Key words: recurrent ischemic stroke, blood lipid spectrum. Danylo Halitsky National Medical University (Lviv)
EFFECT OF METHANOL ON THE ULTRASTRUCTURE OF CHORIORETINAL N.І. Molchanyuk Abstract. Electron-microscopic structure of the chorioretinal complex were investigated (СRC), [choriocapillaries (HC) – retinal pigment epithelium (RPE) – photoreceptor cells (FC)], of white rats in a period of 40 min. to 3 days after a single intraperitoneal dose of methanol 0.75 g/kg body weight. It has been established that RPE cells are the most responsive to the dose of the methanol used. In the dynamics (from 40 min. up to 3 days), they grew destructive changes of mitochondria and elements of smooth endoplasmic reticulum, the smoothness of the basal folds and patchy destruction of the apical microvilli. The changes in CC and FC were similar. By the end of the observation period, these phenomena in the CRC structure spread to a larger number of cells. At the same time, during the whole period of the study, and, in particular, after a day, some signs of recovery of compensatory nature were obvious. Attention is drawn to pronounced reaction of mitochondria, which are energy forming structures of a cell. Key word: methanol, ultrastructure, chorioretinal complex, choriocapillaries, retinal pigment epithelium, photoreceptor cells. SI ”The Filatov
Institute of Eye Diseases and Tissue therapy of the National academy
DIAGNOSING ARRHYTHMIAS WHILE SCREENING SCHOOLCHILDREN D.Yu. Nechytailo Abstract. The study involved 420 children of school age. The children underwent screening determination of arterial pressure and heart rate using automatic blood pressure manometer with arrhythmias sensors. The results were specified by means of recording ECG on a portable cardiograph. The most common heart rhythm disturbances in schoolchildren were respiratory arrhythmia and bundle branch block. Key words: children of school age, ECG, arrhythmia. Bukovinian State Medical University (Chernivtsi)
DIFFERENTIATED COMBINED THERAPY OF POLYCYSTIC OVARY SYNDROME Y.V. Onyshchenko, N.N. Rozhkovska Abstract. Obesity is one of pathognomonic symptoms of polycystic ovary syndrome (PCOS). According to different data sources its frequency among patients with PCOS ranges from 45 to 50 %. Efficiency of differentiated complex treatment of patients with PCOS is studied with taking body mass index (BMI) into account. Obtained data show positive effect of combined infertility treatment that included Metformin for insulin resistance correction as menstrual function and ovulation normalization in 58,7 % of patients with PCOS. Treatment with Metformin results in normalization of luteinizing hormone level which has explicit correlation with risk of 1st trimester miscarriages. Key words: polycystic ovaries syndrome, obesity, insulin resistance, infertility. National Medical University (Odessa)
INVESTIGATION OF CLINICAL - ANAMNESTIC AND
LABORATORY INDEXES CORRELATION IN WOMEN OF EARLY REPRODUCTIVE AGE WITH
EDEMATOUS V.V. Palapa Abstract. An investigation of interconnection between anamnestic and clinical peculiarities of premenstrual syndrome (PMC) in edematous form and hormonal homeostasis indexes in 130 women of early reproductive age has been carried out. The correlation between anamnestic data connected with mental and emotional strain, symptoms which accompany the tissues edema and progesterone, prolactin and cortisol indexes in women with PMC edematous form is traced. Key words: premenstrual syndrome, anamnesis, clinic, hormones M.I. Pirogov Vinnytsya National Medical University
Specific characteristics of lipid peroxidation and аntioxidant О.А. Petrynych Abstract. 44 patients with essential hypertension have been examined in whose blood the indices of lipid peroxidation, аntioxidant system, level of basal insulin have been studied. It has been established that an activation of lipid peroxidation and decrease of аntioxidant system occur in patients with essential hypertension. Basal hyperinsulinemia in patients with essential hypertension is associated with an aggravation of these disorders. Key words: essential hypertension, insulinemia, lipid peroxidation, аntioxidant system. Bukovinian State Medical University (Chernivtsi)
The optimal choice of antihypertensive therapy in patients with L.V. Rasputina Abstract. The aim of our study was to evaluate the effectiveness of various schemes of antihypertensive therapy in patients with chronic obstructive pulmonary disease and concomitant hypertension. Three different schemes of combined therapy with antihypertensive drugs have been assessed. It has been established that prolonged use of a combination of ACE inhibitors and beta –blockers caused a significant decrease in heart rate, in the number of episodes of painful and silent myocardial ischemia, ventricular extrasystoles of high grade. When combined, ACE inhibitor and diuretic decrease the value of the functional class of heart failure, the positive inotropic effect and the quality of life parameters improve significantly. A combination of ramipril and amlodipine had much better antyremodulating effect, and the pressure in the pulmonary arteries dropped. At the same time, all three therapies equally effectively reduced the level of office pressure. Key words: chronic obstructive pulmonary disease, hypertension, antihypertensive therapy. Pirogov National Medical University (Vinnitsa)
SMALL SAPHENOUS
VEIN AND ACUTE VARICOSE THROMBOPHLEBITIS
Sabadosh R.V.1, Pyptiuk O.V.1 , Bohush A.Ye.2 , Skrypko V.D.1, Ryziuk M.D.1 , Abstract. In order to compare the role of the small and great saphenous veins (SSV and GSV) in the development of acute varicose thrombophlebitis in the lower limbs (AVTLL), 236 patients with thrombotic process in 250 limbs have been examined. The number of frequency of thrombosis among the limbs with reflux both in SSV and in GSV presented the role of these veins at AVTLL most objectively. According to this value, there was no statistically significant difference between SSV and GSV (p=0,669): 49,0 % (95 % CI 34,8-63,4 %) versus 45,1 % (95 % CI 31,1-59,7 %). This result showed that traditionally declared higher frequency of thrombosis in GSV among the total number of patients with AVTLL was caused by the more frequent presence of abnormal reflux in this vein solely. The frequency of thrombosis in the tributaries of GSV was significantly higher than the frequency of thrombosis in SSV tributaries, regardless of groups which were compared (all p<0.05). Results of the study indicate that the role of SSV at AVTLL is often underestimated, and a thorough examination of the pathology of its system can improve the treatment effects of the patients with AVTLL. Key words: acute varicose thrombophlebitis in lower limbs, small saphenous vein. National Medical
University (Ivano-Frankivsk),1
THE EFFICACY OF THE SYMPTOMATIC THERAPY OF THE NON-ATOPIC S.I. Sazhyn Abstract. The effectiveness of symptomatic treatment of bronchial asthma in children has been studied. It has been found that patients with non-atopic asthma phenotype were characterized by more severe bronchial obstruction during exacerbations compared with atopic patients. Children afflicted with nonatopic phenotype of the disease were characterized by more pronounced signs of airway obstruction during the whole hospitalization period despite the identical standard regimens in the comparison groups. Key words: bronchial asthma, children, symptomatic treatment, exacerbation. Bukovinian State Medical University (Chernivtsi)
USING CELL INDIRECT REVASCULARIZATION FOR CHRONIC LIMB ISHEMIA R.V. Saliutin Abstract. The problem of treating patients with no reconstruction of peripheral arterial bed is relevant and it still remans open. The results of the pilot study with a simulated limb ischemia, demonstrated the feasibility and efficacy of fetal liver progenitor cells in activating regenerative and recovery processes as well as angiogenesis. The aim of the research was to investigate the clinical efficacy of cell "indirect" revascularization method in the complrehensive treatment of patients with chronic limb ischemia. The developed method of fetal human liver progenitor cells application in treatment of lower limb ischemia is an effective and affordable method of indirect revascularization. This method is indicated for use in patients whose vascular bed can not be reconstructed, and in elderly patients with severe concomitant pathologies. Key words: chronic ischemia, indirect revascularization, progenitor cells, fetal liver. Coordination center of organs, tissues and cell transplantation (Kyiv)
GROWTH-DIFFERENTIATION FACTOR 15, N-TERMINAL PRO-BRAIN NATRIURETIC V.D. Syvolap, Ya.V. Zemlianyi Abstract. Levels of GDF-15, NTproBNP, structural and functional changes of the heart were assessed in 69 patients with postinfarction cardiosclerosis and preserved left ventricular ejection fraction (EF>45 %). We found out that patients with heart failure and preserved ejection fraction after myocardial infarction on the background of arterial hypertension have increased levels of GDF 15 and NTproBNP. These biomarkers were correlated with left ventricular diastolic dysfunction and left atrial volume index. Key words: heart failure, myocardial infarction, growth-differentiation factor 15, N-terminal pro-brain natriuretic peptide. Zaporizhzhia State Medical University (Zaporizhzhia)
correction of hormonal homeostasis by oral contraceptives V.O. Sklyarova Abstract. We evaluated the effectiveness of an application of middle-dose monophasic oral contraceptives (aethinyloestradiolum, desogestrel) for the maintenance of hormonal homeostasis and treatment of the most common complications that occur in the first three months after abortion. The use of oral contraceptives on 7-9th day caused the termination of blood discharge, signs of mastopathia and normalization of menstrual cycle. Thus, administration of drugs maintaining hormonal homeostasis is recommended as an effective method of correction of complications of pregnancy termination in early terms. Key words: medicamentous termination of pregnancy, hormonal homeostasis, oral contraceptives, postabortal contraception. Danylo Halytsky National
Medical University (Lviv),
ELECTRONEUROMYOGRAPHICAL AND IMMUNOLOGICAL PARALELLS IN PATIENTS WITH DIABETES MELLITUS TYPE 2 COMPLICATED WITH POLYNEUROPATHY L.A. Skrypko Abstract. This article presents and analyzes the data from a study of the immune status and the role of immune factors in the progression of polyneuropathy in patients with type 2 diabetes mellitus. The relationship between markers of the functional state of myelin and some parameters of the immune system are ascertained. The most sensitive are tibial nerve characteristics and in most cases – the residual latency period, that is the functional state index of myelin of the most dystal nerves’ segments. It was found that the progression of the polyneuropathy severity is accompanied by the secondary demyelination as a result both of the deepening axonopathy process and some immune disorders. Key words: diabetic polyneuropathy, electroneuromyography, cellular and humoral immunity. SHHE «National Medical University» (Ivano-Frankivsk)
Optimization of therapeutic tactics in patients with acute V.D. Skrypko, Y.A. Klymenko, A.A. Klymenko, M.G. Honchar Abstract. 202 patients with acute small bowel obstruction (ASBO) were involved in a study of clinical and biochemical parameters that characterize the state of endotoxicosis. It has been established that the dilated afferent segment of the small intestine is one of the sources where endointoxication is formed and its functional state, due to an imbalance in the morphological structure, has a direct impact on the surgical treatment results. Key words: intestinal obstruction, endogenous intoxication, reamberin. SHEE «National Medical University»( Ivano-Frankivsk)
PERIODONTAL TISSUES CONDITION IN CARRIAGE GUARDS OF THE LVIV V.I. Struk, V.M. Batih, T.S. Boichuk Abstract. The paper presents data of prevalence and intensity in periodontal tissues diseases in railway carriage guards depending on their age and record of service. Comparative analysis of the periodontal disease dynamics in the guards exposed to harmful professional conditions and those from a comparative group was carried out. Key words: rail transport, chronic catarrhal gingivitis, generalized periodontitis. Bukovinian State Medical University (Chernivtsi)
FASL-MEDIATED APOPTOSIS
IN CHRONIC CARRAGEENAN-INDUCED A.S. Tkachenko Abstract. The levels of sFasL and caspase-3 activity were studied in blood serum of rats with chronic gastroenterocolitis developed after intake of carrageenan during 2 and 4 weeks. It was established that the disease was accompanied by increased activity of caspase-3, more considerable in case of more prolonged carrageenan consumption suggesting activation of apoptosis in chronic intestinal carrageenan-induced inflammation. The elevated level of sFASL was observed, which was higher after 2 weeks of carrageenan intake. It indicated the predominance of FasL-mediated apoptosis of enterocytes in the early stages and the significant role of other mechanisms of apoptosis in the later stages of chronic carrageenan-induced intestinal inflammation. Key words: enterocolitis, carrageenan, rats, sFasL, caspase-3. National Medical University (Kharkiv)
PLATELET-VESSEL HEMOSTASIS IN PATIENTS WITH MYOCARDIAL INFARCTION DEPENDING ON ALLELIC VARIANTS OF GENES ACE (I/D) AND eNOS (894G>T). J.V. Ursuliak, L.P. Sydorchuk Abstract. Changes in the platelet-vascular hemostasis influenced by basic treatment of 102 patients with acute myocardial infarction (AMI) depending on allelic variants of genes angiotensin-converting enzyme (ACE, I/D) and endothelial NO-synthase (eNOS, 894G> T) have been analyzed. The dependence of the treatment efficacy on genotypes and haplotypes of the analyzed genes in relation to hemostasis key-chains has been established. Key words: myocardial infarction, genes АСЕ (І/D), eNOS (T894G), hemostasis, treatment. Bukovinian State Medical University (Chernivtsi)
OZONE THERAPY IN TREATMENT OF PATIENTS WITH UROLITHIASIS COMPLICATED CALCULARY PYELONEPHRITIS AFTER PERFORMING SHOCK-WAVE LITHOTRIPSY O.S. Fedoruk, V.V. Vizniuk, V.I. Zaytsev, K.A. Vladychenko, I.I. Ilyuk Abstract. 35 patients were involved in a study of the effect of the use of intravenous ozone therapy within 10 days for a kidney stone disease with calculous pyelonephritis after applying the distance shock-wave lithotripsy. The positive therapeutic effects of its application , which was manifested in a decrease of lipid peroxidation products in the blood and increased activity of antioxidant enzymes has been established. Key words: calculous pyelonephritis, distance shockwave lithotripsy, lipid peroxidation , enzymes of oxigen inhibitors, lactate, ozone therapy. Bukovinian State Medical University (Chernivtsi)
THE CHANGES IN FIBRINOLYTIC SYSTEM OF THE BLOOD IN THE PERIOPERATIVE O.S. Fedoruk, V.I. Zaytsev, I.I. Iliuk, K.A. Vladychenko, V.V. Vizniuk Abstract. The authors have investigated the dynamics of the parameters for the fibrinolytic activity of the blood serum in operative treatment of patients with benign prostate hyperplasia. Surgical interference was performed to the extent of transurethral resection of the prostate gland. The peculiarities of the state of fibrinolysis during the intraoperative and postoperative periods have been ascertained. The state of fibrinolytic activity of the blood serum in patients with benign prostate hyperplasia and the control group, comprising men of identical age, has been analyzed. Key words: benign prostate hyperplasia, transurethral resection, fibrinolytic activity of the blood. Bukovinian State Medical University (Chernivtsi)
CORRECTIVE INFLUENCE OF ADEMOL ON METABOLISM OF O.A. Khodakovskiy, A.Y. Khodakovskiy Summary. In experiments on the rats with model of acute disorder of encephalic circulation (bilateral carotid occlusion) it was established that introduction of derivate of adamantan 1-adamantilethyloxy-3-morpholino-2 propanol hydrochloride (under conventional name ademol) in dose 2 mg/kg intraabdominal in treatment mode (in an hour after insult and further 1 time a day after every 24 hours during 21 days of cerebral ischemia) better than cerebroprotector citicoline provides decreasing of activity of general NO-synthase (NOS) in the rats’ brain, on which indicated reduced content of stable metabolite of NO and preservation of L-arginine (L-Arg) pool. Such effect of ademol can be one of the key mechanisms of its protective influence on ischemic neurons of the brain and indicate a perspective for creation on its base a new cerebroprotector agent. Key words: ademol, ischemic insult, metabolism of nitrogen monoxide, citicoline. Scientific experimental clinic of Pirogov Memorial Medical University, Vinnitsya
COMPARison of Morphological features of the spinal cord segments V.S. Shkolnikov, Y.Y. Guminskyi, V.A. Tykholaz Abstract. The results of a study of morphometric parameters and structure of the spinal cord segments of human fetuses without abnormalities in the central nervous system compared to a human fetus with myelomeningocele and hydrocephalus are presented in the paper. Some changes both in morphometric parameters values, and in the internal structure of some spinal segments have been detected. Key words: spinal cord, morphometric parameters, hydrocephalus, myelocele, myelomeningocele. M.I. Pyrohov National Medical University (Vinnytsia)
Time organization of physiological functions in mammals. R.Yе. Bulyk, I.V. Herush, V.P. Pishak, Y.Y. Rohovyi Abstract. The results of five year research concerning the mechanism providing circadian rhythms of physiological functions of organs, in particular the kidneys, are presented in the paper. It was proved by light optical, electron microscopy, biochemical and immunohistochemical methods that structures of the organs under the study as well as their functions are strongly subordinate to the duration of the photoperiod. Depression of the pineal body activity (24 hour lighting) causes desynchronization in the structure of suprachiasmatic nucleus (SCN) neurons and in protein c-Fos synthesis. Disturbance of the diurnal rhythm of the SCN pacemaker and of melatonin synthesis is conditioned by the change in the rhythm of epiphysis secretory cells. Besides the SCN and the pineal gland, the hippocampus neurons are involved in the photoperiod disintegration. Key words: pineal gland, photoperiod, kidneys, melatonin, epitalon. Bukovinian State Medical University (Chernivtsi)
“Modern possibilities of Clinical Laboratory diagnostics” I.A. Plesh, А.I. Кshanovska, O.Y. Khomko, L.D. Boreiko, O.V. Makarova Abstract: This article presents the possibilities of clinical laboratory diagnostics, development of new sections of laboratory medicine, such as proteomics and genomics, determination of tumor’s markers, supersensitive molecular genetics techniques and the importance of studying of the possibilities of clinical laboratory diagnostics on the last courses of the future doctors of different specialities. Key words: medical monitoring, diagnostics tests, higher medical education, Medical laboratory assistant, Bachelor. Bukovinian State Medical University (Chernivtsi)
CHARACTERISTICS AND WAYS TO USE CORD BLOOD STEM CELLS (review) D.B. Dombrowskyi, Y.R. Pshyborovska, K.I.Yakovets, V.V. Savin, Abstract. As a result of a review of scientific publications in this study the main advantages of stem cells isolated from cord blood are highlighted , as well as their use in treating various diseases. Key words: cord blood, stem cells. Bukovinian State Medical University (Chernivtsi)
PROSPECTS OF APPLICATION OF EXPERIMENTAL HETEROCYCLIC
I.V. Yeremenchuk Abstract. The main reason for deterioration of the epidemiological situation with tuberculosis (TB) is the change in the biological properties of mycobacteria (MBT) under the influence of anti-TB drugs with the development of poly-and multiresistant strains of M. tuberculosis. Key words: tuberculosis mycobacteria, multiresistant pulmonary tuberculosis, heterocyclic compounds, imidazole derivatives. Bukovinian State Medical University (Chernivtsi)
HYPOGLYCEMIC SYNDROME (LITERATURE REVIEW) P.M. Liashuk1, I.V. Skhodnytskyi2, R.P. Liashuk1, N.I. Stankova3 Abstract. The article presents the literature data about the basic mechanisms regulating blood glucose in normal and pathological conditions, etiology and pathogenesis of hypoglycemia by endocrine and non-endocrine diseases, and also features clinical displays of hypoglycemic syndrome. Key words: hypoglycemia, hypoglycemic syndrome, etiology and pathogenesis, clinical. ¹Bukovinian State Medical University
(Chernivtsi)
OPTICAL SPECTROSCOPY IN MEDICAL DIAGNOSTICS O.I. Olar, O.Yu. Mykytiuk, K.I. Yakovets Abstract. In this review we consider the possibility of optical spectroscopy techniques, namely: optical tomography, optical coherent tomography, polarization-sensitive optical coherent tomography, Raman spectroscopy and photoacoustic tomography. The physical basis of optical diagnostic techniques is the interaction of light with matter, allowing of obtaining structural, biochemical, morphological and physiological information as a result of absorption, scattering, reflection of electromagnetic radiation in the optical range. The advantages of these methods, such as non-invasiveness, absence of side effects, contactlessness, high sensitivity, and high resolution are keys to their success in medical diagnostics. Key words: optical spectroscopy, medical diagnostics. Bukovinian State Medical University (Chernivtsi)
Hypothyroidism and Pregnancy N.V. Pashkovska Abstract. The article presents data on the peculiarities of hypothyroidism course during pregnancy and the postpartum period, and provides information on the current approaches to diagnosis, treatment and prevention of this disease in pregnant women, according to the latest international recommendations developed from positions of evidence based medicine. Key words: pregnancy, hypothyroidism. Bukovinian State Medical University (Chernivtsi)
MOLECULAR-GENETIC MECHANISMS OF PHISIOLOGIC FUNCTIONS TIME V.P. Pishak, R.Y. Bulyk, K.V. Vlasova Abstract. The review presents current data about the course of physiologic processes, controlled by circadian clock system. Deregulation of these mechanisms can cause disorders in cellular signal cascades and lead to pathological processes. Key words: biorythms, temporal genes, melatonin, hypothalamus. Bukovinian State Medical University (Chernivtsi)
ATTITUDE OF MEDICAL WORKERS TOWARDS HEALTHY LIFESTYLE A.S. Biduchak Abstract. Results of a survey about the attitude of medical workers to the healthy lifestyle are presented in the paper. It was found out, that most of the responders believed in the success of preventive medicine at observance of healthy way of life. Key words: medical workers, healthy way of life, prophylaxis, survey. Bukovinian State Medical University (Chernivtsi)
PSYCHOLOGICAL PROBLEMS OF PREGNANCY AND THE PERINATAL PERIOD I.S. Tymkiv Abstract. One of the important challenges that our society faces as a whole and medicine in particular is the formation and development of prenatal culture (or parenthood culture) which will help to raise a generation which treats the childbirth as natural and joyous event in their lives. Childbirth is an expected, mysterious and unforgettable stage of life for each woman. Pain will be soon forgotten – it’s the woman’s nature and the sole moment of the birth of a little wonder will remain in her memory. For the labour to be normal, we should pay special attention to psychological preparation of the pregnant woman. The article deals with the problems of the woman’s attitude to her pregnancy, to the labour and delivery. These data could be used in maternity and paternity schools while developing the curriculum. Key words: pregnancy, psychology, patient . SHEE “National Medical University” (Ivano-Frankivsk)
INDEPENDENT WORK OF STUDENTS AS AN IMPORTANT METHOD OF TRAINING V.I. Klymenko Abstract. Independent work of pharmaceutical faculty students which promotes getting additional knowledge is one of the forms of organizing educational process at the department of clinical pharmacology and pharmacotherapy. Independent work is carried out by using methodical instructions for students which include educational aims, a list of questions, situational problems and tests for self-control as well as references. This kind of study stimulates students to the individual work with literature, to searching information on the Internet, making up abstracts and writing notes. A scientific students’ circle was created at the department in order to increase students’ independent work effectiveness and to strengthen their motivation to perform the work. Key words: independent work of a student, individual work of a student, educational and methodical complex. SHEE «National Medical University» (Ivano-Frankivsk)
FEATURES AND REALIZATION OF "PERMEATING PROGRAM" FOR TRAINING N.S. Mykhailovska Abstract. This work provides ways of teaching process optimization of the discipline “General practice – family medicine” in the undergraduate stage in higher medical educational institutions of Ukraine considering the experience gained in Zaporozhzhia State Medical University. The basic aspects of the “Permeating program” realization concerning the training of medical students of IV level of accreditation in practical skills and learning techniques necessary to work as general practitioners – family doctors. Key words: primary health care, family doctor, undergraduate training, ways of optimization, seamless program. State Medical University (Zaporizhzhia)
PSYCHOLOGICAL-PEDAGOGICAL CULTURE OF THE PROFESSORS’ STUFF OF THE HIGHER MEDICAL EDUCATIONAL ESTABLISHMENT IN THE CONTEXT OF THE O.M. Panko Abstract. Ukrainian society has entered the phase of reformation of higher education, including medical education, according to the standards of Bologna process. Our state faces presently the choice of new educational paradigm which aims at removing disparity between the requirements of the society and the level of educational services, at replacing the aim of comprehensive personality development with the aim of maximal development of person's abilities to self-realization and self-education. The importance of Bologna process is shown in the article; it is proven that it is an extraordinarily difficult and prolonged process, which requires, first of all, the correction of psychological and pedagogic culture of teaching staff of higher medical institutions, which is ready to reconstruct cardinally the educational process. It is difficult to over-estimate the urgency of the problem, as it concerns both the education and its reformation, as well as the process of integration of our country into Europe. Key words: Bologna process, psychological and pedagogic culture, medical education. National Medical University (Ivano-Frankivsk)
METHODICAL APPROACHES TO Teaching chemistry for the preparatory O.O. Perepelytsia Abstract. Methodical approaches to teaching chemistry under conditions of limited amount of teaching hours for students with different learning abilities that are studying at the preparatory department for Ukrainian citizens of Bukovinian medical university are considered in this article. Based on the results of mental activity diagnosis for each group of teenagers methodical techniques for working with students were developed. It is proposed to use explanatory, illustrative training with problematic elements while teaching basic, principal topics, and for the sections that are a logical conclusion of basic topics to use the method of proactive knowledge for the groups of students with creative and constructive mindset. Systematization and structuring of studied material should be conducted through usage of graph-logic schemes and tables. It is advisable to practice skills in all groups of students regardless of their level of knowledge wherein for the groups with creative and constructive mindset tasks modeled from real situations and problems of increased complexity should be solved. Extracurricular independent work should be organized with different learning abilities of students taken in mind by developing tasks that are differentiated by their difficulty rate. Key words: students, mindset, teaching chemistry, methodical approaches. Bukovіnian State Medical University (Chernivtsi)
METHODOLOGICAL APPROACHES TO HUMUNITARIAN TRAINING L.B. Shutak, H.V. Navchuk Abstract. The article defines the features of teaching humanities, including Ukrainian language for professional purposes in the context of the formation and training future specialists in the fields of medicine and pharmacy. The fact that professional communication is one of the most important ways of assessing the intellectual level of an individual, the basis of their modern life and professional growth has been emphasized. Key words: patriotic education, national consciousness and self consciousness, intellectual level of individual, civic activity, national elite, Ukrainian language for specific purposes, language proficiency. Bukovinian State Medical University (Chernivtsi)
ACHIEVEMENTS OF THE RESEARCHERS OF BUKOVINIAN STATE
O.I. Voloshyn, T.N. Boychuk, O.I. Ivashchuk, I.F. Meshchyshen Abstract. The article presents the results of 23 years of research by the staff of Bukovinian State Medical University on the issue of herbal medicine, apitherapy and healthy food. The expediency of further scientific research in this field and their compliance with the current international trends in medicine and pharmacy have been substantiated. Key words: herbal medicine, apitherapy, health food, scientific research, professional training. Bukovinian State Medical University (Chernivtsi)
INVESTMENT OF MEMBERS OF DERMATOVENEREOLOGY DEPARTMENT OF O.I. Denysenko, T.P. Vysochanska, M.P. Perepichka, M.Y. Haevska, L.O. Hulei, Y.P. Karvatska Abstract. In the article are presented the historical and modern data on the participation of members of dermatovenereology department of Bukovinian State Medical University in the formation and development of dermatovenereological service on the territory of Chernivtsi region (Northern Bukovyna). Key words: BSMU, history, dermatovenereology, treating work. Bukovinian State Medical University (Chernivtsi)
HISTORY OF FORMATION, THE
PRESENT AND THE FUTURE OF THE DEPARTMENT A.H. Iftodii, I.V. Shkvarkovskyi, O.S. Fedoruk, V.I. Zaitsev, V.I. Hrebeniuk,
O.V. Bilyk, V.B. Reva, Abstract. The article describes the historical stages of development of the Department of Surgery and Urology of Bukovinian State Medical University. It gives biographical information on prominent scientists who worked at the department in different years. The scientific achievements of the department staff and work assignments in practical public health are presented. Key words: Department of Surgery and Urology, Bukovinian State Medical University, Chernivtsi. Bukovinian State Medical University (Chernivtsi)
SCIENTIFIC ACHIEVEMENTS AND PROSPECTS OF DEPARTMENT OF INTERNAL O.S. Khukhlina, O.V. Zaliavska Abstract. The study has described the history of the Department of Internal Medicine, Clinical Pharmacology and Occupational Diseases, directions of scientific researches, teaching and clinical work, accomplishments and achievements in the field of medicine since its foundation and the prospects for future work. Key words: Bukovinian State Medical University, internal medicine, hospital therapy. Bukovinian State Medical University (Chernivtsi)
HISTORY OF ASSISTED REPRODUCTIVE TECHNOLOGY FOR TREATING T.A. Yuzko, О.M. Yuzko, A.B. Zhebchuk, L.V. Zakharenko, L.T.Savchuk, I.V. Chemorkina, K.A. Vladychenko Abstract. Historical facts of the introduction of assisted reproductive technologies for the treatment of infertility in Bukovуna are presented in the paper. Key words: assisted reproductive technology (ART), infertility, donation. Bukovinian State Medical University (Chernivtsi) |
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